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Like many exploited child stars, Jennette McCurdy had more than her fair share of struggles growing up -- this is her journey to adulthood and personal agency.

Bella Ramsay was just 11 years old when she landed her first professional role as Lady Lyanna on "Game of Thrones," and it changed her life in numerous ways.

After Blake Lively played Serena van der Woodsen on "Gossip Girl," her whole life changed - professionally, personally, and in unexpected ways.

"Thor" catapulted actor Chris Hemsworth from obscurity to superstardom, with his life and career going through massive changes as a result.

Although Elizabeth Olsen had a promising career before Marvel knocked on her door, the role of the Scarlet Witch sent her into the stratosphere.

In a recent interview, Jason Beghe spoke about how playing Voight for the duration of "Chicago P.D." had affected how he saw police officers.

Margot Robbie took off like a rocket with her role in Martin Scorsese's "The Wolf of Wall Street," with the part changing her life and career forever.

Tom Holland's career reached new heights when he was cast as the MCU's Spider-Man, but it also changed the actor's life forever.

"Fire Country" continues to misuse one of the show's major characters, and fans of the CBS drama are starting to wish the squad would just fire them.

After shooting to stardom as the lead in the Transformers franchise, a series of controversies and criminal allegations have followed Shia LaBeouf's career.

"Twilight" rocketed Robert Pattinson from complete unknown to superstar and heartthrob. Here's how his journey as Edward Cullen transformed his life and career.

Keanu Reeves experienced a breakthrough when "The Matrix" premiered. Here's how the actor's life changed following the film's release.

The role of Khal Drogo lasted only 10 episodes, and hindered Jason Momoa's career development, until Zack Snyder called with the role of a lifetime.

For better and, in some cases, for worse, Natalie Portman's breakout role in the "Star Wars" prequel trilogy changed her life and career for good.

Sony's recent acquisition of Bungie may have some lasting effects on the film industry in the coming years. Here's how.

Julia Fox shot to stardom after her role in "Uncut Gems," and ever since, her career has been a sight to see. Here's how the film changed Fox's life.

The latest trailer for "Dungeons & Dragons: Honor Among Thieves" gives fans of the game plenty of reasons to be excited about this new cinematic adaptation.

Mark Ruffalo's rise to the Hollywood A-list began with an indie hit called "You Can Count on Me." Here's how the film changed his life forever.

Another massive acquisition has just taken place, as the goliath Amazon has swallowed up yet another company: the 97-year-old Metro-Goldwyn-Mayer Studios.

Pedro Pascal got his big break playing Oberyn Martell on "Game of Thrones." At this point, it's safe to say that the role changed the trajectory of his life.

He's coming back in "Deadpool & Wolverine," but it all started for Hugh Jackman with "X-Men" in 2000 - and his career has never been the same since.

2011's "Green Lantern" is one of the most notorious superhero movie failures in Hollywood history, and it changed Ryan Reynolds' life in numerous ways.

The 2013 film "Rhymes for Young Ghouls" served as a "career-defining moment" for Devery Jacobs, as she admitted in a recent interview.

"Fantastic Four" was supposed to take Jessica Alba's career to the next level. Instead it eventually led her to a different kind of success altogether.

The actor explained how the Mike Schur-created show changed the way she looks at life.

"Deadpool 2" star Rob Delaney, playing the ordinary, mustachioed X-Force member Peter, was never the same after Fox's "Deadpool" sequel with Ryan Reynolds.

Starring in one of the greatest sci-fi sagas has had a different impact on its cast. These are the actors who were never the same after their "Star Wars" roles.

The lead of "Mayfair Witches" became a movie and TV star in the 2010s but wasn't truly recognized for her acting until "The White Lotus" in 2021.

"The Goldbergs" was not Hayley Orrantia's first jump into television, but it's had a huge impact on her life.

It can be scary enough just to watch it all play out onscreen — so how does the cast feel as they bring these stories to life? For better or for worse, American Horror Story seems to be the kind of show that makes a permanent impact on an actor. Here's how it's changed these actors' lives.