Steve Urkel's love interest, Myra Monkhouse was originally a guest appearance spot, but soon she became a recurring role and an intrinsic part of the ensemble. Thomas passed away from stomach cancer in 1998, at the age of 30.

The future “Glee” star only appeared in three episodes, but her performance led to roles in “The Fresh Prince of Bel-Air,” and “The Young and the Restless.” In 2020, she disappeared during a boating trip with her son, tragically the 33-year-old’s body was found five days later.

Jenner portrayed Lieutenant Lou Murtaugh, Carl’s incompetent boss whose saint-like patience made him one of the few characters who could tolerate Urkel. He passed away in 2016 at the age of 75, following a long battle with leukemia.

Hemsley is perhaps best known for playing George Jefferson, but he also had a memorable guest role playing Carl's boss, Captain Marion Savage. In 2021, at the age of 74, he succumbed to superior vena cava syndrome.

LeNoire’s critically acclaimed turn as Mother Winslow was integral to the show’s success. She passed away in 2002, at the age of 90. Her commitment to diversity in the arts lead to the creation of the Rosie Award named in her honor, further cementing her storied legacy.